Triamcinolone acetonide injectable suspension for suprachoroidal use in the treatment of macular edema associated with uveitis

Expert Rev Ophthalmol. 2022;17(3):165-173. doi: 10.1080/17469899.2022.2114456. Epub 2022 Aug 21.

ABSTRACT

INTRODUCTION: Macular edema due to noninfectious uveitis is a sight-threatening complication that is routinely treated with corticosteroids. Triamcinolone acetonide injectable suspension for suprachoroidal use (Xipere™) is an alternative treatment option for patients with non-infectious uveitis associated macular edema.

AREAS COVERED: This review describes the recently FDA approved triamcinolone acetonide injectable suspension that can be injected into the suprachoroidal space. This physiological space is between the sclera and choroid. This allows for therapeutic targeting of the retina and choroid. This review highlights published clinical trials for this novel drug preparation.

EXPERT OPINION: Suprachoroidal administration of triamcinolone acetonide has shown improvement in vision and inflammation in studies with non-infectious uveitis associated macular edema. This unique delivery method suggests the potential to decrease side effects of anterior segment exposure such as glaucoma and cataract, but head-to-head trials are needed for further study of safety and efficacy. Additionally, there are promising prospective studies underway for utilization of the suprachoroidal space for other diseases including macular degeneration, diabetic macular edema, and ocular tumors.

PMID:36060305 | PMC:PMC9438525 | DOI:10.1080/17469899.2022.2114456