Expert Rev Ophthalmol . 2020;15(4):221-231. doi: 10.1080/17469899.2020.1767597. Epub 2020 Jun 25. ABSTRACT INTRODUCTION: Modulation of epigenetic mechanisms that contribute to retinal development may render the eye susceptible to age-related macular degeneration (AMD). Progressi…
Expert Rev Ophthalmol. 2020;15(4):221-231. doi: 10.1080/17469899.2020.1767597. Epub 2020 Jun 25.
ABSTRACT
INTRODUCTION: Modulation of epigenetic mechanisms that contribute to retinal development may render the eye susceptible to age-related macular degeneration (AMD). Progression of AMD involves alterations of epigenome such as CpG methylation and histone modifications, and study of the epigenetic regulation of molecular/ cellular pathways associated with AMD might identify target epigenetic markers for treatment of AMD.
AREAS COVERED: In this review, we provide an overview of the influence of epigenetic factors on signaling pathways/ related genes associated with AMD, mainly hypoxia, angiogenesis, inflammation, complement, and oxidative stress; and discuss the critical role of microRNAs in AMD.
EXPERT OPINION: Better understanding of epigenetic-mediated and microRNA-mediated regulation of the AMD disease-related pathways would help to assess the risk of developing AMD besides providing valuable insight on potential target candidates for AMD therapy.
PMID:33732291 | PMC:PMC7963213 | DOI:10.1080/17469899.2020.1767597