Agreements between 24-2 and 24-2 C test grids for chloroquine/hydroxychloroquine retinopathy patients and high-risk patients

Eye (Lond). 2026 May 5. doi: 10.1038/s41433-026-04462-9. Online ahead of print.

ABSTRACT

PURPOSE: To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk.

METHODS: A prospective, cross-sectional study of 75 participants who underwent CQ/HCQ retinopathy screening using the SITA Standard 24-2, SITA Faster 24-2 C, optical coherence tomography, fundus autofluorescence, and a dilated eye examination on the same day. Participants were categorized into retinopathy and non-retinopathy groups by graders. The agreement between the two visual field (VF) tests was assessed using Bland-Altman plots.

RESULTS: Among the 75 participants, 10 (13.3%) were diagnosed with CQ/HCQ retinopathy. Bland-Altman plots show good agreement in median deviation (MD), pattern standard deviation (PSD), and central mean sensitivity (CMS) between tests. The concordance coefficient was 0.89-0.93. Significant differences in MD, PSD, and CMS were observed between the retinopathy and non-retinopathy groups for both VF tests (P ≤ 0.02). However, within each group, the results of both VF tests were comparable across all parameters (P = 0.12-0.79), except for PSD in the non-retinopathy group. The SITA Faster 24-2 C test had a significantly shorter testing duration.

CONCLUSIONS: The SITA Standard 24-2 and SITA Faster 24-2 C tests showed similar efficacy and strongly positive agreement in screening for CQ/HCQ retinopathy. However, the SITA Faster 24-2 C minimized the testing time. The addition of testing points within the central 10-degree field did not enhance the detection of CQ/HCQ retinopathy in the Thai population.

PMID:42082615 | DOI:10.1038/s41433-026-04462-9